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Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

5 Feb 2018

Abstract excerpt

Scientific research on human neural stem cells and cerebral organoids has confirmed the congenital neurotropic and neurodestructive nature of the Zika virus. However, the extent to which prenatal ZIKV infection is associated with more subtle brain alterations, such as epigenetic changes, remains ill defined. Here, we address the question of whether ZIKV infection induces DNA methylation changes with the potential...

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PMID: 29435496
DOI: 10.1128/msystems.00219-17

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