Article
Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.
Science (New York, N.Y.) - 7 Jul 2017
Chavali Pavithra L, Stojic Lovorka, Meredith Luke W, Joseph Nimesh, Nahorski Michael S, Sanford Thomas J, Sweeney Trevor R, Krishna Ben A, Hosmillo Myra, Firth Andrew E, Bayliss Richard, Marcelis Carlo L, Lindsay Susan, Goodfellow Ian, Woods C Geoffrey, Gergely Fanni
Abstract excerpt
A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential for cortical development, but the cause of this neurotropism remains obscure. Here we report that the neural RNA-binding protein Musashi-1 (MSI1) interacts with the Zika genome and enables viral replication. Zika infection disrupts...
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