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Phenotype of htgA (mbiA), a recently evolved orphan gene of Escherichia coli and Shigella, completely overlapping in antisense to yaaW.

FEMS microbiology letters - 1 Jan 2014

Fellner Lea, Bechtel Niklas, Witting Michael A, Simon Svenja, Schmitt-Kopplin Philippe, Keim Daniel, Scherer Siegfried, Neuhaus Klaus

Abstract excerpt

Overlapping embedded genes, such as htgA/yaaW, are assumed to be rare in prokaryotes. In Escherichia coli O157:H7, gfp fusions of both promoter regions revealed activity and transcription start sites could be determined for both genes. Both htgA and yaaW were inactivated strand specifically by introducing a stop codon. Both mutants exhibited differential phenotypes in biofilm formation and metabolite levels in a...

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PMID: 24111745
DOI: 10.1111/1574-6968.12288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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