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Article

CrossPlan: systematic planning of genetic crosses to validate mathematical models.

Bioinformatics (Oxford, England) - 1 Jul 2018

Pratapa Aditya, Adames Neil, Kraikivski Pavel, Franzese Nicholas, Tyson John J, Peccoud Jean, Murali T M

Abstract excerpt

Motivation: Mathematical models of cellular processes can systematically predict the phenotypes of novel combinations of multi-gene mutations. Searching for informative predictions and prioritizing them for experimental validation is challenging since the number of possible combinations grows exponentially in the number of mutations. Moreover, keeping track of the crosses needed to make new mutants and planning...

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PMID: 29432533
DOI: 10.1093/bioinformatics/bty072
PMCID: PMC6022539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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