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Article

An effective framework for reconstructing gene regulatory networks from genetical genomics data.

Bioinformatics (Oxford, England) - 15 Jan 2013

Flassig R J, Heise S, Sundmacher K, Klamt S

Abstract excerpt

MOTIVATION: Systems Genetics approaches, in particular those relying on genetical genomics data, put forward a new paradigm of large-scale genome and network analysis. These methods use naturally occurring multi-factorial perturbations (e.g. polymorphisms) in properly controlled and screened genetic crosses to elucidate causal relationships in biological networks. However, although genetical genomics data contain...

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PMID: 23175757
DOI: 10.1093/bioinformatics/bts679

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