EIF3G is associated with narcolepsy across ethnicities.

doi:10.1038/ejhg.2015.4

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Article

EIF3G is associated with narcolepsy across ethnicities.

European journal of human genetics : EJHG - 1 Nov 2015

Holm Anja, Lin Ling, Faraco Juliette, Mostafavi Sara, Battle Alexis, Zhu Xiaowei, Levinson Douglas F, Han Fang, Gammeltoft Steen, Jennum Poul, Mignot Emmanuel, Kornum Birgitte R

Abstract excerpt

Type 1 narcolepsy, an autoimmune disease affecting hypocretin (orexin) neurons, is strongly associated with HLA-DQB1*06:02. Among polymorphisms associated with the disease is single-nucleotide polymorphism rs2305795 (c.*638G>A) located within the P2RY11 gene. P2RY11 is in a region of synteny conserved in mammals and zebrafish containing PPAN, EIF3G and DNMT1 (DNA methyltransferase 1). As mutations in DNMT1 cause...

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Identifiers

PMID: 25669430
DOI: 10.1038/ejhg.2015.4
PMCID: PMC4613472

Genes

DNMT1
PPAN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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