Article
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Human genetics - 1 Oct 2010
Shimada Mihoko, Miyagawa Taku, Kawashima Minae, Tanaka Susumu, Honda Yutaka, Honda Makoto, Tokunaga Katsushi
Abstract excerpt
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and a pathological manifestation of rapid eye movement during sleep. Narcoleptic pathogenesis is triggered by both genetic and environmental factors. Recently, development of genome-wide association studies (GWAS) has identified new genetic factors, with many more susceptibility genes yet to be elucidated. Using a new...
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