Article
Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2018
Clarke Megan A, Gradissimo Ana, Schiffman Mark, Lam Jessica, Sollecito Christopher C, Fetterman Barbara, Lorey Thomas, Poitras Nancy, Raine-Bennett Tina R, Castle Philip E, Wentzensen Nicolas, Burk Robert D
Abstract excerpt
Purpose: Human papillomavirus (HPV) DNA methylation testing is a promising triage option for women testing HPV positive during cervical cancer screening. However, the extent to which methylation indicates precancer for all 12 carcinogenic HPV types has not been evaluated.Experimental Design: In this nested case-control study, we tested up to 30 cases of precancer [cervical intraepithelial neoplasia grade 3...
Topics
- Adult
- Aged
- Biomarkers, Tumor
- Case-Control Studies
- Computational Biology
- CpG Islands
- DNA Methylation
- DNA, Viral
- Female