Article

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signalling pathway

2023-07-14

Abstract excerpt

Myocardial ischemia-reperfusion injury (MIRI) is the main reason for the poor prognosis of patients with ischemic cardiomyopathy (ICM). To date, the mechanism of MIRI remains unknown. As members of the silent information regulator 2 (SIR2) family, SIRT1 and SIRT3 have been shown to play critical roles in protecting cardiomyocytes against MIRI, but whether SIRT1 and SIRT3 interact to regulate mitophagy and their as...

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Literature Corpus work: cc6fb2c9-2d0f-51e2-8d3b-2a1fb9628a95
DOI: 10.21203/rs.3.rs-3151670/v1

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