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Article

Bioinformatics analysis of non-synonymous variants in the KLF genes related to cardiac diseases.

Gene - 15 Apr 2018

Ferreira Katyana Kaline Silva, de Morais Gomes Enéas Ricardo, de Lima Filho José Luiz, Castelletti Carlos Henrique Madeiros, Martins Danyelly Bruneska Gondim

Abstract excerpt

Kruppel-like Factors (KLF) are responsible for regulating many genes involved in physiological and pathological processes. They are characterized by three conserved zinc-fingers in the DNA-binding domain, wherein mutations could affect the binding efficiency and transcription regulation. This study aimed to perform bioinformatics analysis to determine the most deleterious non-synonymous variants in KLFs involved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29408733
DOI: 10.1016/j.gene.2018.01.085

Genes

KLF15
KLF5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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