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Article

Synonymous variants in IRX4 and their association with congenital heart disease: an in-silico functional assessment.

Molecular biology reports - 15 Jul 2026

Maddhesiya Jyoti, Jain Dharmendra, Kumar Ashok, Mohapatra Bhagyalaxmi

Abstract excerpt

BACKGROUND: Synonymous variants are often overlooked during genetic screening, however current reports forecasted their significant biological impact and inevitably considered pathogenic. These silent changes in genome significantly affect the mRNA structure and stability and hence, alter the protein expression and function. IRX4 is an essential transcription factor for cardiogenesis and reported to be associated...

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Identifiers

PMID: 42455270
DOI: 10.1007/s11033-026-12304-w

Genes

IRX4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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