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Article

KLF13 loss-of-function variation contributes to familial congenital heart defects.

European review for medical and pharmacological sciences - 1 Nov 2020

Wang S-S, Wang T-M, Qiao X-H, Huang R-T, Xue S, Dong B-B, Xu Y-J, Liu X-Y, Yang Y-Q

Abstract excerpt

OBJECTIVE: Congenital heart defect (CHD) represents the most common form of human developmental abnormality and contributes to substantial morbidity, mortality, and socioeconomic burden worldwide. Accumulating evidence underscores the strong genetic basis of CHD. Nevertheless, CHD is of pronounced genetic heterogeneity, and the genetic determinants underlying CHD in most patients are still unclear. This study was...

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PMID: 33215447
DOI: 10.26355/eurrev_202011_23617

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