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Article

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

Nature genetics - 1 Mar 2018

Kanai Masahiro, Akiyama Masato, Takahashi Atsushi, Matoba Nana, Momozawa Yukihide, Ikeda Masashi, Iwata Nakao, Ikegawa Shiro, Hirata Makoto, Matsuda Koichi, Kubo Michiaki, Okada Yukinori, Kamatani Yoichiro

Abstract excerpt

Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 quantitative traits in 162,255 Japanese individuals. Overall, we identified 1,407 trait-associated loci (P < 5.0 × 10-8), 679 of which were novel. By incorporating 32...

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PMID: 29403010
DOI: 10.1038/s41588-018-0047-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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