Article
IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.
The Journal of pathology - 1 Apr 2015
Huaux François, Lo Re Sandra, Giordano Giulia, Uwambayinema Francine, Devosse Raynal, Yakoub Yousof, Panin Nadtha, Palmai-Pallag Mihaly, Rabolli Virginie, Delos Monique, Marbaix Etienne, Dauguet Nicolas, Couillin Isabelle, Ryffel Bernhard, Renauld Jean-Christophe, Lison Dominique
Abstract excerpt
Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from alveolar macrophages serving as a local reservoir for the expansion of activated phagocytic macrophages. By exploring lung...
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