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Article

Mechanisms, models and biomarkers in amyotrophic lateral sclerosis

1 May 2013

Abstract excerpt

The last 30 years have seen a major advance in the understanding of the clinical and pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with frontotemporal dementia. Multiple, seemingly disparate biochemical pathways converge on a common clinical syndrome characterized by progressive loss of upper and lower motor neurons. Pathogenic themes in ALS include excitotoxicity, oxidative...

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PMID: 23678877
DOI: 10.3109/21678421.2013.778554

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