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Article

Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL‑60 cells with tolerance to arsenic trioxide and contribution of leukemia stem cells

6 Nov 2017

Abstract excerpt

The present study selected and characterized a multidrug‑resistant HL‑60 human acute promyelocytic leukemia cell line, HL‑60/RS, by exposure to stepwise incremental doses of doxorubicin. The drug‑resistant HL‑60/RS cells exhibited 85.68‑fold resistance to doxorubicin and were cross‑resistant to other chemotherapeutics, including cisplatin, daunorubicin, cytarabine, vincristine and etoposide. The cells...

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PMID: 29399180
DOI: 10.3892/ol.2017.7353

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