Article
Genomic Profile of Urothelial Carcinoma of the Upper Tract from Ureteroscopic Biopsy: Feasibility and Validation Using Matched Radical Nephroureterectomy Specimens.
European urology focus - 1 May 2019
Bagrodia Aditya, Audenet Francois, Pietzak Eugene J, Kim Kwanghee, Murray Katie S, Cha Eugene K, Sfakianos John P, Iyer Gopa, Singla Nirmish, Arcila Maria, Bochner Bernard H, Al-Ahmadie Hikmat A, Solit David B, Coleman Jonathan A
Abstract excerpt
Urothelial carcinoma of the upper tract (UTUC) presents specific challenges regarding accurate staging and tumor sampling. We aimed to assess the feasibility of applying next-generation sequencing to biopsy specimens and gauged the concordance of their genetic profiles with matched radical nephroureterectomy (RNU) specimens. Of the 39 biopsy specimens collected, 36 (92%) had adequate material for sequencing using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.