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Article

The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Neurobiology of aging - 1 Jun 2018

Engelman Corinne D, Darst Burcu F, Bilgel Murat, Vasiljevic Eva, Koscik Rebecca L, Jedynak Bruno M, Johnson Sterling C

Abstract excerpt

Recent studies have found an association between functional variants in TREM2 and PLD3 and Alzheimer's disease (AD), but their effect on cognitive function is unknown. We examined the effect of these variants on cognitive function in 1449 participants from the Wisconsin Registry for Alzheimer's Prevention, a longitudinal study of initially asymptomatic adults, aged 36-73 years at baseline, enriched for a parental...

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Source

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Identifiers

PMID: 29395285
DOI: 10.1016/j.neurobiolaging.2017.12.025
PMCID: PMC5924624

Genes

PLD3
TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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