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Article

BMP4 knockdown of NCSCs leads to aganglionosis in the middle embryonic stage.

Molecular medicine reports - 1 Apr 2018

Li Hong-Bo, Jin Xian-Qing, Jin Xin, Guo Zheng-Hua, Ding Xiong-Hui, Wang Quan, Liu Rui-Zhuo

Abstract excerpt

Transplacental bone morphogenetic protein (BMP)4 RNA interference (RNAi) is a technique used to knockdown genes in embryos. BMP4 are essential for the development of nervous system in the differentiation of neural crest stem cells (NCSCs). The failure of differentiation and migration of NCSCs may lead to aganglionosis. In the present study, pregnant mice were divided into three groups: Ringer's group, pSES group...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29393463
DOI: 10.3892/mmr.2018.8519

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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