Early Death of Neural Crest Cells is Responsible for Total Enteric Aganglionosis in <i>Sox10</i>^<i>Dom</i>/<i>Sox10</i>^<i>Dom</i> Mouse Embryos

Abstract excerpt

Intestinal aganglionosis results from homologous genetic defects in humans and mice, including mutations of Sox10, which encodes a transcription factor expressed in neural crest cells. To gain insight into the embryological basis for this condition, the phenotype and pathogenesis of intestinal aganglionosis in Sox10(Dom)/Sox10(Dom) embryos were studied. The distribution of enteric neural precursors and other...

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