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Article

Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system

29 Dec 2011

Abstract excerpt

Formation of the enteric nervous system (ENS) from migratory neural crest-derived cells that colonize the primordial gut involves a complex interplay among different signaling molecules. The bone morphogenetic proteins (BMPs), specifically BMP2 and BMP4, play a particularly important role in virtually every stage of gut and ENS development. BMP signaling helps to pattern both the anterior-posterior axis and the...

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PMID: 22213745
DOI: 10.1002/dneu.22002

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