Article
Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
Investigative ophthalmology & visual science - 1 Feb 2018
Bailey Jessica N Cooke, Gharahkhani Puya, Kang Jae H, Butkiewicz Mariusz, Sullivan David A, Weinreb Robert N, Aschard Hugues, Allingham R Rand, Ashley-Koch Allison, Lee Richard K, Moroi Sayoko E, Brilliant Murray H, Wollstein Gadi, Schuman Joel S, Fingert John H, Budenz Donald L, Realini Tony, Gaasterland Terry, Scott William K, Singh Kuldev, Sit Arthur J, Igo Robert P, Song Yeunjoo E, Hark Lisa, Ritch Robert, Rhee Douglas J, Vollrath Douglas, Zack Donald J, Medeiros Felipe, Vajaranant Thasarat S, Chasman Daniel I, Christen William G, Pericak-Vance Margaret A, Liu Yutao, Kraft Peter, Richards Julia E, Rosner Bernard A, Hauser Michael A, Craig Jamie E, Burdon Kathryn P, Hewitt Alex W, Mackey David A, Haines Jonathan L, MacGregor Stuart, Wiggs Janey L, Pasquale Louis R
Abstract excerpt
Purpose: Sex hormones may be associated with primary open-angle glaucoma (POAG), although the mechanisms are unclear. We previously observed that gene variants involved with estrogen metabolism were collectively associated with POAG in women but not men; here we assessed gene variants related to testosterone metabolism collectively and POAG risk. Methods: We used two datasets: one from the United States (3853...
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