Article
Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.
Eye (London, England) - 1 Jun 2014
Kang J H, Loomis S J, Yaspan B L, Bailey J C, Weinreb R N, Lee R K, Lichter P R, Budenz D L, Liu Y, Realini T, Gaasterland D, Gaasterland T, Friedman D S, McCarty C A, Moroi S E, Olson L, Schuman J S, Singh K, Vollrath D, Wollstein G, Zack D J, Brilliant M, Sit A J, Christen W G, Fingert J, Forman J P, Buys E S, Kraft P, Zhang K, Allingham R R, Pericak-Vance M A, Richards J E, Hauser M A, Haines J L, Wiggs J L, Pasquale L R
Abstract excerpt
AIMS: Vascular perfusion may be impaired in primary open-angle glaucoma (POAG); thus, we evaluated a panel of markers in vascular tone-regulating genes in relation to POAG. METHODS: We used Illumina 660W-Quad array genotype data and pooled P-values from 3108 POAG cases and 3430 controls from the combined National Eye Institute Glaucoma Human Genetics Collaboration consortium and Glaucoma Genes and Environment...
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