Article
Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies.
Journal of virology - 1 Nov 2014
Hraber Peter, Korber Bette T, Lapedes Alan S, Bailer Robert T, Seaman Michael S, Gao Hongmei, Greene Kelli M, McCutchan Francine, Williamson Carolyn, Kim Jerome H, Tovanabutra Sodsai, Hahn Beatrice H, Swanstrom Ronald, Thomson Michael M, Gao Feng, Harris Linda, Giorgi Elena, Hengartner Nicholas, Bhattacharya Tanmoy, Mascola John R, Montefiori David C
Abstract excerpt
UNLABELLED: Neutralizing antibodies (nAbs) are a high priority for vaccines that aim to prevent the acquisition of HIV-1 infection. Vaccine effectiveness will depend on the extent to which induced antibodies neutralize the global diversity of circulating HIV-1 variants. Using large panels of genetically and geographically diverse HIV-1 Env-pseudotyped viruses and chronic infection plasma samples, we unambiguously...
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