Article
Novel RET mutations in macedonian patients with medullary thyroid carcinoma: genotype-phenotype correlations.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) - 1 Jan 2015
Jovanovic R, Kostadinova-Kunovska S, Janevska V, Bogoeva B, Spasevska L, Miladinova D, Ugrinska A, Zdraveska-Kochovska M, Trajkov D, Petrusevska G
Abstract excerpt
Medullary thyroid carcinomas (MTCs) are rare neoplasms comprising 2-10% of all thyroid malignnancies. More than 75% are sporadic tumors and the remainder is familial and MEN2 related. Both sporadic and syndromic MTCs frequently show mutations in the RET proto-oncogene. It has been noted that some MTC cases present an indolent, and some an aggressive clinical course. Ki-67 expression is generally low, with...
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