Article
Role of L1 in neural development: what the knockouts tell us.
Molecular and cellular neurosciences - 1 Sept 1998
Kamiguchi H, Hlavin M L, Lemmon V
Abstract excerpt
Mutations in the cell adhesion molecule L1 cause severe developmental anomalies in the human nervous system. Recent descriptions of L1 gene knock-out mice from three research groups demonstrate that these mice are strikingly similar to humans with mutations in the L1 gene. In both humans and mice...
Topics
- Animals
- Cerebellum
- Disease Models, Animal
- Gene Expression Regulation, Developmental
- Humans
- Leukocyte L1 Antigen Complex
- Membrane Glycoproteins
- Mice
- Mice, Knockout
- Mutation
- Neural Cell Adhesion Molecules
- Pyramidal Tracts