Article
Genetic estimators of DNA methylation provide insights into the molecular basis of polygenic traits.
Translational psychiatry - 31 Jan 2018
Freytag Virginie, Vukojevic Vanja, Wagner-Thelen Holger, Milnik Annette, Vogler Christian, Leber Markus, Weinhold Leonie, Böhmer Anne C, Riedel-Heller Steffi, Maier Wolfgang, de Quervain Dominique J-F, Ramirez Alfredo, Papassotiropoulos Andreas
Abstract excerpt
The large biological distance between genetic risk loci and their mechanistic consequences in the tissue of interest limits the ability to establish functionality of susceptibility variants for genetically complex traits. Such a biological gap may be reduced through the systematic study of molecular mediators of genomic action, such as epigenetic modification. Here, we report the identification of robust genetic...
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