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Article

Epigenetic Signatures Associated with Different Levels of Differentiation Potential in Human Stem Cells

12 Nov 2009

Abstract excerpt

BACKGROUND: The therapeutic use of multipotent stem cells depends on their differentiation potential, which has been shown to be variable for different populations. These differences are likely to be the result of key changes in their epigenetic profiles. METHODOLOGY/PRINCIPAL FINDINGS: to address this issue, we have investigated the levels of epigenetic regulation in well characterized populations of pluripotent...

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PMID: 19915669
DOI: 10.1371/journal.pone.0007809

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