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Article

Substrate-induced structural alterations of Mycobacterial mycothione reductase and critical residues involved.

FEBS letters - 1 Feb 2018

Kumar Arvind, Subramanian Manimekalai Malathy Sony, Grüber Gerhard

Abstract excerpt

Redox homeostasis is a prerequisite for survival of the pathogen Mycobacterium tuberculosis (Mtb) which employs the low molecular weight thiol mycothiol (MSH). The Mycobacterial NADPH-dependent mycothione reductase (MtMtr), composed of an NADPH-, FAD-, and a dimerization-domain connected by linkers, regulates the balance of oxidized-reduced MSH. Here, we demonstrate by small-angle X-ray scattering, that...

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PMID: 29377100
DOI: 10.1002/1873-3468.12984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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