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Article

Structural insights on mouse L-threonine dehydrogenase: A regulatory role of Arg180 in catalysis.

Journal of structural biology - 1 Dec 2015

He Chao, Huang Xianyu, Liu Yanhong, Li Fudong, Yang Yang, Tao Hongru, Han Chuanchun, Zhao Chen, Xiao Yazhong, Shi Yunyu

Abstract excerpt

Mouse L-threonine dehydrogenase (mTDH), which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily and mediates threonine catabolism, plays pivotal roles in both powerful biosynthesis and signaling in mouse stem cells and has a regulatory residue Arg180. Here we determined three crystal structures of mTDH: wild-type (WT) in the apo form; in complex with NAD(+) and a substrate analog, glycerol, or...

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PMID: 26492815
DOI: 10.1016/j.jsb.2015.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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