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Article

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils.

Scientific reports - 4 Jul 2018

Kaur Gundeep, Kaundal Soni, Kapoor Srajan, Grimes Jonathan M, Huiskonen Juha T, Thakur Krishan Gopal

Abstract excerpt

CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex. Available crystal structures have captured two distinct, monomeric and domain-swapped homodimeric, oligomeric states of CarD. However, the actual oligomeric state of CarD in solution and its biological relevance has...

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Identifiers

PMID: 29973616
DOI: 10.1038/s41598-018-28290-4
PMCID: PMC6031611

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