Article
Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Rajwani Rahim, Yam Wing Cheong, Zhang Ying, Kang Yu, Wong Barry Kin Chung, Leung Kenneth Siu Sing, Tam Kingsley King Gee, Tulu Ketema Tafess, Zhu Li, Siu Gilman Kit Hang
Abstract excerpt
Background: Development of improved therapeutics against tuberculosis (TB) is hindered by an inadequate understanding of the relationship between disease severity and genetic diversity of its causative agent, Mycobacterium tuberculosis. We previously isolated a hypervirulent M. tuberculosis strain H112 from an HIV-negative patient with an aggressive disease progression from pulmonary TB to tuberculous...
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