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Article

Delineating the evolutionary pathway to multidrug-resistant outbreaks of a Mycobacterium tuberculosis L4.1.2.1/Haarlem sublineage.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jul 2024

Dekhil Naira, Mardassi Helmi

Abstract excerpt

OBJECTIVES: We sought to capture the evolutionary itinerary of the Mycobacterium tuberculosis L4.1.2.1/Haarlem sublineage in northern Tunisia, where it caused a major multidrug-resistant (MDR) tuberculosis outbreak in a context strictly negative for HIV infection. METHODS: We combined whole genome sequencing and Bayesian approaches using a representative collection of drug-susceptible and drug-resistant...

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Identifiers

PMID: 38697608
DOI: 10.1016/j.ijid.2024.107077

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