Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.

Oncogene - 9 Feb 2006

Longley D B, Wilson T R, McEwan M, Allen W L, McDermott U, Galligan L, Johnston P G

Abstract excerpt

c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5. We studied the effect of c-FLIP on the apoptotic response to chemotherapies used in colorectal cancer (CRC) (5-fluorouracil, oxaliplatin and irinotecan). Simultaneous downregulation of both c-FLIP splice forms c-FLIP(L) and c-FLIP(S) with siRNA synergistically enhanced chemotherapy-induced apoptosis in p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 8
Share to Caspase Inhibitors
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fas Receptor

Share to Protein Splicing

Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Share to Receptors, Tumor Necrosis Factor

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 16247474
DOI: 10.1038/sj.onc.1209122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.PMID 16247474Read ↗

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer TherapySemantic proximity Read ↗

Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29.Semantic proximity Read ↗

FLIP as an Anti-Cancer Therapeutic TargetSemantic proximity Read ↗

FLIP as a therapeutic target in cancerSemantic proximity Read ↗

Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer.Semantic proximity Read ↗

Prognostic and therapeutic relevance of c‐<scp>FLIP</scp> in acute myeloid leukaemiaSemantic proximity Read ↗

TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.Semantic proximity Read ↗

Quercetin Enhances 5-fluorouracil Sensitivity by Regulating the Autophagic Flux and Inducing Drp-1 Mediated Mitochondrial Fragmentation in Colorectal Cancer CellsSemantic proximity Read ↗

Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic ApproachSemantic proximity Read ↗

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.Semantic proximity Read ↗

The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR MutationsSemantic proximity Read ↗

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIPshortSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.