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Article

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases.

Nature reviews. Cancer - 1 Nov 2012

Verstraete Kenneth, Savvides Savvas N

Abstract excerpt

Intracellular signalling cascades initiated by class III receptor tyrosine kinases (RTK-IIIs) and their cytokine ligands contribute to haematopoiesis and mesenchymal tissue development. They are also implicated in a wide range of inflammatory disorders and cancers. Recent snapshots of RTK-III ectodomains in complex with cognate cytokines have revealed timely insights into the structural determinants of RTK-III...

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PMID: 23076159
DOI: 10.1038/nrc3371

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