Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compromised JMJD6 Histone Demethylase Activity Affects VHL Gene Repression in Preeclampsia

24 Jan 2018

Abstract excerpt

Context: The von Hippel Lindau (VHL) protein is a key executor of the cellular hypoxic response that is compromised in preeclampsia, a serious disorder complicating 5% to 7% of pregnancies. To date, the mechanisms controlling VHL gene expression in the human placenta remain elusive. Objective: We examined VHL epigenetic regulation in normal pregnancy and in preeclampsia, a pathology characterized by placental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Congenital Diaphragmatic Hernia Studies
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29373688
DOI: 10.1210/jc.2017-02197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compromised JMJD6 Histone Demethylase Activity Affects VHL Gene Repression in PreeclampsiaPMID 29373688Read ↗

Dysregulation of Oxygen Sensing/Response Pathways in Pregnancies Complicated by Idiopathic Intrauterine Growth Restriction and Early-Onset PreeclampsiaSemantic proximity Read ↗

Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct PathologiesSemantic proximity Read ↗

The Genomics and Genetics of Oxygen HomeostasisSemantic proximity Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsiaSemantic proximity Read ↗

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension.Semantic proximity Read ↗

Dysregulation of hypoxia-inducible factor-1α (Hif1α) expression in the Hmox1-deficient placentaSemantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

Hypoxia and podocyte-specificVhlhdeletion confer risk of glomerular diseaseSemantic proximity Read ↗

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.Semantic proximity Read ↗

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axisSemantic proximity Read ↗

Vhl deletion in <i>Dmp1</i> -expressing cells alters MEP metabolism and promotes stress erythropoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.