Dysregulation of hypoxia-inducible factor-1α (Hif1α) expression in the Hmox1-deficient placenta

Abstract excerpt

Severe hypoxia exists in placentas during early pregnancy, with reoxygenation during mid-gestation. Hypoxia-inducible factor-1α (Hif1α), an oxygen sensor, initiates placental vascular development. We have shown that the placental vasculature in Hmox1-deficient (Hmox1+/−, Het) pregnancies is impaired, with morphological defects similar to Hif1α-deficient placentas. Whole wild-type (WT) and Het mouse placentas were...

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