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Article

The genetic architecture of mitochondrial dysfunction in Parkinson's disease.

Cell and tissue research - 1 Jul 2018

Larsen S B, Hanss Z, Krüger R

Abstract excerpt

Mitochondrial impairment is a well-established pathological pathway implicated in Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain have been found in post-mortem brains from sporadic PD patients. Furthermore, several disease-related genes are linked to mitochondrial pathways, such as PRKN, PINK1, DJ-1 and HTRA2 and are associated with mitochondrial impairment. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29372317
DOI: 10.1007/s00441-017-2768-8
PMCID: PMC6015629

Genes

HSPA9
HTRA2
PINK1
PRKN
RHOT1
SNCA
TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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