Article
Mitochondrial quality control in neurodegenerative diseases.
Biochimie - 1 May 2014
Dupuis Luc
Abstract excerpt
Mutations causing genetic forms of Parkinson's disease or hereditary neuropathies have been recently shown to affect key molecular players involved in the recycling of defective mitochondria, most notably PARKIN, PINK1, Mitofusin 2 or dynein heavy chain. Interestingly, the same pathways are also indirectly targeted by multiple other mutations involved in familial forms of amyotrophic lateral sclerosis,...
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