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Article

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage.

PLoS pathogens - 1 Jan 2018

Reh Lucia, Magnus Carsten, Kadelka Claus, Kühnert Denise, Uhr Therese, Weber Jacqueline, Morris Lynn, Moore Penny L, Trkola Alexandra

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To enable this, properties that render HIV-1 envelopes (Env) capable of eliciting bnAb responses need to be defined. Here, we followed the evolution of the V2 apex directed bnAb lineage VRC26 in the HIV-1 subtype C superinfected donor...

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Share to Antibodies, Neutralizing
Share to Antibody Formation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigenic Variation

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to Immune Evasion

Share to Neutralization Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 29370298
DOI: 10.1371/journal.ppat.1006825
PMCID: PMC5806907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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