Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis

24 Jan 2018

Abstract excerpt

A DNA methylation (DNAm) signature (the "Horvath clock") has been proposed as a measure of human chronological and biological age. We determined peripheral blood DNAm in patients with nonalcoholic steatohepatitis (NASH) and assessed whether accelerated aging occurs in these patients. DNAm signatures were obtained in patients with biopsy-proven NASH and stage 2-3 fibrosis. The DNAm profile from one test and two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Liver Disease Diagnosis and Treatment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29367468
DOI: 10.1172/jci.insight.96685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitisPMID 29367468Read ↗

Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age accelerationSemantic proximity Read ↗

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic SignatureSemantic proximity Read ↗

Obesity accelerates epigenetic aging of human liverSemantic proximity Read ↗

Epigenetic Alterations in Blood Mirror Age-Associated Dna Methylation and Gene Expression Changes in Human LiverSemantic proximity Read ↗

Biological aging accelerates hepatic fibrosis: Insights from the NHANES 2017-2020 and genome-wide association study analysis.Semantic proximity Read ↗

Accelerated aging of skeletal muscle and the immune system in patients with chronic liver diseaseSemantic proximity Read ↗

Reverse Inflammaging: Long-term effects of HCV cure on biological ageSemantic proximity Read ↗

Obesity accelerates epigenetic aging in middle-aged but not in elderly individualsSemantic proximity Read ↗

Alcohol Consumption and Methylation-Based Measures of Biological AgeSemantic proximity Read ↗

Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLDSemantic proximity Read ↗

HIV, pathology and epigenetic age acceleration in different human tissuesSemantic proximity Read ↗

A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.