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Article

Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation.

International journal of radiation oncology, biology, physics - 1 Nov 2010

Zeitlin Benjamin D, Spalding Aaron C, Campos Marcia S, Ashimori Naoki, Dong Zhihong, Wang Shaomeng, Lawrence Theodore S, Nör Jacques E

Abstract excerpt

PURPOSE: To investigate the effect of a metronomic (low-dose, high-frequency) small-molecule inhibitor of Bcl-2 (TW-37) in combination with radiotherapy on microvascular endothelial cells in vitro and in tumor angiogenesis in vivo. METHODS AND MATERIALS: Primary human dermal microvascular endothelial cells were exposed to ionizing radiation and/or TW-37 and colony formation, as well as capillary sprouting in...

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Source

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Identifiers

PMID: 20675079
DOI: 10.1016/j.ijrobp.2010.04.024
PMCID: PMC2946486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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