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Article

Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

27 Nov 2018

Abstract excerpt

Tumor cure with conventional fractionated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand break (DSB) misrepair. Here we report that single-dose radiotherapy (SDRT), a disruptive technique that ablates more than 90% of human cancers, operates a distinct dual-target mechanism, linking acid sphingomyelinase-mediated (ASMase-mediated) microvascular perfusion defects to...

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PMID: 30480549
DOI: 10.1172/jci97631

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