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Article

Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.

Bioorganic & medicinal chemistry letters - 15 Feb 2018

Chitneni Satish K, Reitman Zachary J, Spicehandler Rebecca, Gooden David M, Yan Hai, Zalutsky Michael R

Abstract excerpt

Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) are commonly found in gliomas. AGI-5198, a potent and selective inhibitor of the mutant IDH1 enzyme, was radiolabeled with radioiodine and fluorine-18. These radiotracers were evaluated as potential probes for imaging mutant IDH1 expression in tumors with positron emission tomography (PET). Radioiodination of AGI-5198 was achieved using a tin...

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Identifiers

PMID: 29366652
DOI: 10.1016/j.bmcl.2018.01.015
PMCID: PMC5817038

Genes

IDH1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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