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Article

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours.

Molecules (Basel, Switzerland) - 11 Jun 2022

Weber Valérie, Arnaud Lucie, Dukic-Stefanovic Sladjana, Wenzel Barbara, Roux Valérie, Chezal Jean-Michel, Lai Thu-Hang, Teodoro Rodrigo, Kopka Klaus, Miot-Noirault Elisabeth, Deuther-Conrad Winnie, Maisonial-Besset Aurélie

Abstract excerpt

Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma). These mutated variants of IDH (mIDH) acquire a neomorphic activity, namely, conversion of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate involved in tumourigenesis. Thus, mIDHs have emerged as highly promising therapeutic...

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PMID: 35744895
DOI: 10.3390/molecules27123766
PMCID: PMC9228733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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