Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer.

Biochemical and biophysical research communications - 12 Mar 2010

Murugan Avaniyapuram Kannan, Bojdani Ermal, Xing Mingzhao

Abstract excerpt

Mutations in the genes for isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) have been recently identified in glioblastoma. In the present study, we investigated IDH1 and IDH2 mutations in follicular thyroid cancer (FTC) and anaplastic thyroid cancer (ATC), with the latter,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Transformation, Neoplastic
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isocitrate Dehydrogenase

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Polymorphism, Single Nucleotide

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 20171178
DOI: 10.1016/j.bbrc.2010.02.095
PMCID: PMC2838977

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20171178-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer.PMID 20171178Read ↗

Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas.Semantic proximity Read ↗

Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma.Semantic proximity Read ↗

A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma.Semantic proximity Read ↗

Analysis of the IDH1 codon 132 mutation in brain tumors.Semantic proximity Read ↗

Virtual mutagenesis of isocitrate dehydrogenase 1 involved in glioblastoma multiforme.Semantic proximity Read ↗

Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.Semantic proximity Read ↗

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors.Semantic proximity Read ↗

Analysis of IDH1 and IDH2 mutations in Japanese glioma patients.Semantic proximity Read ↗

R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.Semantic proximity Read ↗

Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies.Semantic proximity Read ↗

IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.Semantic proximity Read ↗

Functional alteration of canine isocitrate dehydrogenase 2 (IDH2) via an R174K mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.