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Article

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.

Cancer research - 15 Aug 2014

Chaumeil Myriam M, Larson Peder E Z, Woods Sarah M, Cai Larry, Eriksson Pia, Robinson Aaron E, Lupo Janine M, Vigneron Daniel B, Nelson Sarah J, Pieper Russell O, Phillips Joanna J, Ronen Sabrina M

Abstract excerpt

Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade glioma and secondary glioblastoma, represent an early pathogenic event, and are associated with epigenetically driven modulations of metabolism. Of particular interest is the recently uncovered relationship between the IDH1 mutation and decreased activity of the branched-chain amino acid transaminase 1 (BCAT1)...

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Source

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Identifiers

PMID: 24876103
DOI: 10.1158/0008-5472.CAN-14-0680
PMCID: PMC4134724

Genes

IDH1
BCAT1

Provenance

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