Article
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
Scientific reports - 23 Jan 2018
Juenemann Katrin, Jansen Anne H P, van Riel Luigi, Merkx Remco, Mulder Monique P C, An Heeseon, Statsyuk Alexander, Kirstein Janine, Ovaa Huib, Reits Eric A
Abstract excerpt
Many neurodegenerative diseases, such as Huntington's disease, are hallmarked by the formation of intracellular inclusion bodies (IBs) that are decorated with ubiquitin, proteasomes and chaperones. The apparent enrichment of ubiquitin and components involved in protein quality control at IBs suggests local ubiquitin-dependent enzymatic activity. In this study, we examine recruitment of ubiquitin to IBs of...
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