Article
Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease.
Journal of Crohn's & colitis - 27 Apr 2018
Visschedijk Marijn C, Spekhorst Lieke M, Cheng Shih-Chin, van Loo Ellen S, Jansen B H Dianne, Blokzijl Tjasso, Kil Hyunsuk, de Jong Dirk J, Pierik Marieke, Maljaars Jeroen P W J, van der Woude C Janneke, van Bodegraven Adriaan A, Oldenburg Bas, Löwenberg Mark, Nieuwenhuijs Vincent B, Imhann Floris, van Sommeren Suzanne, Alberts Rudi, Xavier Ramnik J, Dijkstra Gerard, Nico Faber Klaas, Aldaz C Marcelo, Weersma Rinse K, Festen Eleonora A M
Abstract excerpt
Background and Aims: Crohn's disease [CD] is a chronic inflammatory disease with unpredictable behaviour. More than half of CD patients eventually develop complications such as stenosis, for which they then require endoscopic dilatation or surgery, as no anti-fibrotic drugs are currently available. We aim to identify disease-modifying genes associated with fibrostenotic CD. Methods: We performed a within-case...
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