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Structure mapping of dengue and Zika viruses reveals functional long-range interactions

29 Mar 2019

Abstract excerpt

Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus function. Here, we perform structure and interaction mapping on four DENV and ZIKV strains inside virions and in infected cells. Comparative analysis of SHAPE reactivities across serotypes nominates potentially functional regions that are highly...

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PMID: 30926818
DOI: 10.1038/s41467-019-09391-8

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